Identifying skeletal-related events for prostate cancer in routinely collected hospital data
Parry, M. Cowling, T. Sujenthiran, A. Nossiter, J. Berry, B. Cathcart, P. Clarke, Noel W Payne, H. Aggarwal, van der Meulen, J
Parry, M.
Cowling, T.
Sujenthiran, A.
Nossiter, J.
Berry, B.
Cathcart, P.
Clarke, Noel W
Payne, H.
Aggarwal,
van der Meulen, J
Citations
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Abstract
Purpose or Objective
Non-osteoporotic skeletal-related events (SREs) are
clinically important markers of disease progression in
prostate cancer. We developed and validated an approach
to identify SREs in men with prostate cancer using
routinely-collected data.
Material and Methods
Patients diagnosed with prostate cancer between January
2010 and December 2013 were identified in the National
Prostate Cancer Audit, based on English cancer registry
data. A coding framework was developed based on
diagnostic and procedure codes in linked national
administrative hospital and routinely-collected
radiotherapy data to identify SREs occurring before
December 2015. Two coding definitions of SREs were
assessed based on whether the SRE codes were paired with
a bone metastasis code (‘specific definition’) or used in
isolation (‘sensitive definition’). We explored the validity
of both definitions by comparing the cumulative incidence
of SREs from time of diagnosis according to prostate cancer
stage at diagnosis with death as a competing risk.
Results
We identified 40,063, 25,234 and 13,968 patients
diagnosed with localised, locally advanced and metastatic
disease, respectively. Using the specific definition, we
found that the 5-year cumulative incidence of SREs was
0.9% in patients with localised disease, 5.4% in patients
with locally advanced disease, and 38.8% in patients with
metastatic disease. Using the sensitive definition, the
corresponding cumulative incidence figures were 8.4%,
13.4%, and 40.7%, respectively.
Conclusion
The comparison of the cumulative incidence of SREs
identified in routinely collected hospital data, based on a
specific coding definition in patients diagnosed with
different prostate cancer stage, supports their validity as
a clinically important marker of cancer progression.
Description
Date
2020
Publisher
Collections
Keywords
Type
Meetings and Proceedings
Citation
Parry M, Cowling T, Sujenthiran A, Nossiter J, Berry B, Cathcart P, et al. PO-1178: Identifying skeletal-related events for prostate cancer in routinely collected hospital data. Radiotherapy and Oncology . 2020 Nov;152:S620.