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Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials.
Trumper, M Ross, P J Cunningham, David Norman, A Hawkins, Robert E Seymour, M T Harper, P Iveson, T Nicolson, M Hickish, T
Trumper, M
Ross, P J
Cunningham, David
Norman, A
Hawkins, Robert E
Seymour, M T
Harper, P
Iveson, T
Nicolson, M
Hickish, T
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Abstract
The aim of this study was to determine the benefits of chemotherapy for oesophago-gastric cancer (OGC) in patients 70 years and above (> or =70) in comparison to younger patients. 1080 patients were enrolled into three randomised controlled trials assessing fluorouracil-based combination chemotherapy. Patients received either a platinum-containing regimen (ECF, MCF), PVI 5-FU (protracted venous infusion of 5-fluorouracil)+/-mitomycin C (MMC), or FAMTX. Of the 1080 patients randomised, 257 (23.8%) were aged > or =70 years. There were no significant differences in the incidence of grades 3/4 toxicity between the two cohorts. Objective and symptomatic response rates, failure-free and overall survival were not significantly different. In a multivariate analysis, independent prognostic factors for survival were performance status and locally advanced disease, not age. Patients > or =70 years with OGC obtained similar benefits from palliative chemotherapy with respect to symptomatic response, tumour regression and survival, without increased toxicities.
Description
Date
2006-05
Publisher
Collections
Keywords
Oesophageal Cancer
Stomach Cancer
Stomach Cancer
Type
Article
Citation
Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: A pooled analysis of three clinical trials. 2006, 42 (7):827-34 Eur. J. Cancer