DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival.
Dazzi, H Thatcher, Nick Hasleton, Philip S Swindell, Ric
Dazzi, H
Thatcher, Nick
Hasleton, Philip S
Swindell, Ric
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Abstract
In a retrospective study, surgical specimens of 136 patients with nonsmall cell lung cancer, were investigated for DNA content by flow cytometry. Seventy per cent of all tumours were aneuploid. Aneuploidy was a statistically significant factor for shorter survival and was independent of tumour size, histology, grade of differentiation, regional lymph node involvement, age and sex (P less than 0.02). A high proliferation index (greater than 7.5%) was also a prognostically unfavourable factor and was observed significantly more often in tumours where the majority of cells expressed epidermal growth factor receptor.
Description
Date
1990-05
Publisher
Collections
Keywords
Cancer DNA
Lung Cancer
Lung Cancer
Type
Article
Citation
DNA analysis by flow cytometry in nonsmall cell lung cancer: relationship to epidermal growth factor receptor, histology, tumour stage and survival. 1990, 84 (3):217-23 Respir Med