One-electron reduction of adriamycin: properties of the semiquinone.
Land, Edward J Mukherjee, Tulsi Swallow, A John Bruce, J M
Land, Edward J
Mukherjee, Tulsi
Swallow, A John
Bruce, J M
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Abstract
Pulse radiolysis of aqueous solutions containing adriamycin and redox indicators of known one-electron reduction potential (E1) shows that its E1 at pH 7 is -328 mV (vs NHE). The variation E1 with pH in the range 6-12 shows that the net charge on the semiquinone at pH 7 is zero. As well as the pKa values of 2.9 and greater than or equal to 14 established independently, the semiquinone has a pKa close to 9.2. The new data enable the structure and likely reactivity of the semiquinone to be specified.
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1983-08
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One-electron reduction of adriamycin: properties of the semiquinone. 1983, 225 (1):116-21 Arch Biochem Biophys