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Lack of correlation between stem-cell proliferation and radiation- or smoking-associated cancer risk.

Little, M
; 
Hendry, Jolyon H
; 
Puskin, J
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Abstract
A recent paper by Tomasetti and Vogelstein (Science 2015 347 78-81) suggested that the variation in natural cancer risk was largely explained by the total number of stem-cell divisions, and that most cancers arose by chance. They proposed an extra-risk score as way of distinguishing the effects of the stochastic, replicative component of cancer risk from other causative factors, specifically those due to the external environment and inherited mutations.
Authors
Little, M
Hendry, Jolyon H
Puskin, J
Affiliation
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland
Description
Date
2016
Publisher
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All Christie Publications
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Article
Citation
Lack of Correlation between Stem-Cell Proliferation and Radiation- or Smoking-Associated Cancer Risk. 2016, 11 (3):e0150335 PLoS ONE
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URI
http://hdl.handle.net/10541/605242
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