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Irreversible electroporation in pancreatic ductal adenocarcinoma: Is there a role in conjunction with conventional treatment?
De Liguori Carino, N O'Reilly, D Siriwardena, A Radhakrishna, Ganesh
De Liguori Carino, N
O'Reilly, D
Siriwardena, A
Radhakrishna, Ganesh
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Abstract
The incidence of pancreatic ductal adenocarcinoma (PDAC) is rapidly increasing. Up to 30% of patients present with locally advanced disease and therefore are not candidates for surgery. Locally advanced pancreatic cancer (LAPC) is an emerging entity lacking in level III evidence-based recommendations for its treatment. Currently, systemic chemotherapy is the main treatment for LAPC. However, due to lack of response or disease progression, downsizing of the tumour, making it resectable is successful in only a small proportion of patients. Radiotherapy is often advocated to improve local disease control if there is stability following chemotherapy. Recently, Irreversible Electroporation (IRE), a novel non-thermal ablation technique, has been proposed for the treatment of LAPC.
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Date
2018-10
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Article
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Irreversible electroporation in pancreatic ductal adenocarcinoma: Is there a role in conjunction with conventional treatment? 2018, 44(10): 1486-1493 Eur J Surg Oncol