Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma.
Oguejiofor, Kenneth K Hall, J Slater, C Betts, G Hall, G Dovedi, S Stern, Peter L West, Catharine M L
Oguejiofor, Kenneth K
Hall, J
Slater, C
Betts, G
Hall, G
Dovedi, S
Stern, Peter L
West, Catharine M L
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Abstract
Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than those with HPV-negative tumours. There is interest in de-escalating their treatment but strategies are needed for risk stratification to identify subsets with a poor prognosis. This study investigated tumour-infiltrating lymphocytes (TILs) in relation to HPV tumour status and patient survival.
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Date
2015-09-15
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Article
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Stromal infiltration of CD8 T cells is associated with improved clinical outcome in HPV-positive oropharyngeal squamous carcinoma. 2015, 113 (6):886-93 Br J Cancer