Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy.
Thatcher, Nick Palmer, Michael K Swindell, Ric Crowther, Derek
Thatcher, Nick
Palmer, Michael K
Swindell, Ric
Crowther, Derek
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Abstract
Thirty-eight patients with metastatic melanoma were evaluated immunologically prior to chemoimmunotherapy. The assays used included recall antigen skin hypersensitivity; lymphocyte count; nonspecific T, non-T, and K cell lymphocytotoxicity; and T and B cell rosette enumeration. Survival curves were computed for each of four ranges of values of a given immunologic test. The higher ranges of positive skin tests, lymphocyte count, cytotoxicity, and T and B subpopulation numbers were consistently associated with the longer survivals. The differences reached statistical significance for non-T cell cytotoxicity and B and T cell peripheral blood counts. Pretreatment immune reactivity, particularly that involvingg non-T cell function, appears related to length of survival.
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Date
1978
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Collections
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Article
Citation
Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy. 1978, 4 (1):59-70 Med. Pediatr. Oncol.