Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: radiation damage in a mesenchymal system in vivo.
Neal, J Valerie Potten, Christopher S
Neal, J Valerie
Potten, Christopher S
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Abstract
The effect of low dose ionizing radiation from a variety of sources on the murine small intestinal and colonic pericryptal fibroblast sheath (PCFS) has been investigated. Ultrastructural and light microscopic changes seen within 3 hours after radiation resembles the mode of cell death known as apoptosis. The apoptotic index (AI) was shown to rise steadily for 4 hours after irradiation, and then to return to control levels by 10 hours. 137Cs gamma-irradiation over a range of doses from 0-803 cGy caused an increase in AI from control values of 1-2 per cent to a plateau level of approximately 8.5 per cent for doses above 40 cGy. Investigation of the response of the PCFS to doses of 137Cs and 60Co gamma-irradiation and X-irradiation below 40 cGy demonstrated a steady increase with dose in AI. The survival curve for the radiosensitive subpopulation susceptible to death through apoptosis as a consequence of exposure to non-acute doses of radiation has a D0 of 10.6 cGy and an extrapolation number of 2.3.
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1981-02
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Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: radiation damage in a mesenchymal system in vivo. 1981, 39 (2):175-83 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.