The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.
Hornillo-Araujo, Ana R Burrell, Adam J M Aiertza, Miren K Shibata, Takayuki Hammond, David M Edmont, Dolores Adams, Harry Margison, Geoffrey P Williams, David M
Hornillo-Araujo, Ana R
Burrell, Adam J M
Aiertza, Miren K
Shibata, Takayuki
Hammond, David M
Edmont, Dolores
Adams, Harry
Margison, Geoffrey P
Williams, David M
Citations
Altmetric:
Abstract
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analogue displayed activity.
Description
Date
2007
Publisher
Collections
Keywords
Type
Article
Citation
The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. 2007, 26 (8-9):1099-102 Nucleosides Nucleotides Nucleic Acids