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Magnetic resonance imaging-guided adaptive radiation therapy: A 'game changer' for prostate treatment?
Pathmanathan, A van As, N Kerkmeijer, L Christodouleas, J Lawton, C Vesprini, D van der Heide, U Frank, S Nill, S Oelfke, U
Pathmanathan, A
van As, N
Kerkmeijer, L
Christodouleas, J
Lawton, C
Vesprini, D
van der Heide, U
Frank, S
Nill, S
Oelfke, U
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Abstract
Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.
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2018-02-01
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Magnetic resonance imaging-guided adaptive radiation therapy: A 'game changer' for prostate treatment? 2018, 100 (2):361-373 Int J Radiat Oncol Biol Phys