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The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
Lawrence, Nicholas J Rennison, David McGown, Alan T Hadfield, John A
Lawrence, Nicholas J
Rennison, David
McGown, Alan T
Hadfield, John A
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Abstract
The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.
Description
Date
2003-11-03
Publisher
Collections
Keywords
Cancer DNA
Type
Article
Citation
The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents. 2003, 13 (21):3759-63 Bioorg. Med. Chem. Lett.