Potent antimitotic and cell growth inhibitory properties of substituted chalcones.
Ducki, Sylvie W Forrest, R Hadfield, John A Kendall, A Lawrence, N J McGown, Alan T Rennison, David
Ducki, Sylvie W
Forrest, R
Hadfield, John A
Kendall, A
Lawrence, N J
McGown, Alan T
Rennison, David
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Abstract
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.
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Date
1998-05-05
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Article
Citation
Potent antimitotic and cell growth inhibitory properties of substituted chalcones. 1998, 8 (9):1051-6 Bioorg. Med. Chem. Lett.