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Independent clonal origin of T- and B-cell clones in a composite lymphoma.
Deane, M Amlot, P Pappas, H Norton, John D
Deane, M
Amlot, P
Pappas, H
Norton, John D
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Abstract
We present a detailed immunohistological and genotypic analysis of an unusual case in which a peripheral T-cell lymphoma, with features of Lennert's and angioimmunoblastic lymphoma, occurred after treatment of a low grade plasmacytoid lymphoma. By analysis of immunoglobulin and T-cell receptor genes, we show that the two diseases had an independent clonal origin at the level of lymphoid commitment. However, by employing a novel polymerase chain reaction-based technique for analysis of B-cell clonality, we show the persistence of a residual minor clonal B-cell population in the subsequent T-cell lymphoma. Only 2 previous cases of composite lymphoma involving B- and T-cell clones have been demonstrated by molecular analysis. This study underlines the immunophenotypic and genotypic heterogeneity of peripheral T-cell lymphomas and illustrates an unusual disease course in which a T-cell lymphoma has arisen in the context of, and perhaps as a consequence of, a B-cell lymphoma.
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Description
Date
1991
Publisher
Collections
Keywords
Second Primary Cancer
Leukaemia
Leukaemia
Type
Article
Citation
Independent clonal origin of T- and B-cell clones in a composite lymphoma. 1991, 15 (9):811-7 Leuk. Res.