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Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.
Cortes, J Tamura, K DeAngelo, D de Bono, J Lorente, D Minden, M Uy, G Kantarjian, H Chen, L Gandhi, V
Cortes, J
Tamura, K
DeAngelo, D
de Bono, J
Lorente, D
Minden, M
Uy, G
Kantarjian, H
Chen, L
Gandhi, V
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Abstract
Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours.
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2018-05-16
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Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers. 2018, Br J Cancer