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Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.
Somervaille, Tim C P Matheny, Christina J Spencer, Gary J Iwasaki, Masayuki Rinn, John L Witten, Daniela M Chang, Howard Y Shurtleff, Sheila A Downing, James R Cleary, Michael L
Somervaille, Tim C P
Matheny, Christina J
Spencer, Gary J
Iwasaki, Masayuki
Rinn, John L
Witten, Daniela M
Chang, Howard Y
Shurtleff, Sheila A
Downing, James R
Cleary, Michael L
Citations
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Abstract
The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of human AML, LSCs exhibit variable frequencies that correlate with the initiating MLL oncogene and are maintained in a self-renewing state by a transcriptional subprogram more akin to that of embryonic stem cells (ESCs) than to that of adult stem cells. The transcription/chromatin regulatory factors Myb, Hmgb3, and Cbx5 are critical components of the program and suffice for Hoxa/Meis-independent immortalization of myeloid progenitors when coexpressed, establishing the cooperative and essential role of an ESC-like LSC maintenance program ancillary to the leukemia-initiating MLL/Hox/Meis program. Enriched expression of LSC maintenance and ESC-like program genes in normal myeloid progenitors and poor-prognosis human malignancies links the frequency of aberrantly self-renewing progenitor-like cancer stem cells (CSCs) to prognosis in human cancer.
Description
Date
2009-02-06
Publisher
Keywords
Myeloid Leukaemia
Stem Cells
Embryonic Stem Cells
Adult Stem Cells
Stem Cells
Embryonic Stem Cells
Adult Stem Cells
Type
Article
Citation
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. 2009, 4 (2):129-40 Cell Stem Cell