Effect of verapamil on daunorubicin accumulation in lymphocytes isolated from patients undergoing chemotherapy.
McGown, Alan T Murphy, D Crowther, Derek Fox, Brian W
McGown, Alan T
Murphy, D
Crowther, Derek
Fox, Brian W
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Abstract
Verapamil was shown to be capable of increasing intracellular daunorubicin levels in normal lymphocytes isolated from patients undergoing chemotherapy for epithelial ovarian cancer. The extent of the increase in daunorubicin accumulation was variable, occurring in the range of 0-123% as compared with intracellular daunorubicin levels attained in the absence of verapamil. No similar effect was seen in lymphocytes isolated from healthy volunteers. A tentative explanation of these data may be the induction of multidrug resistance (mdr)-like characteristics in normal lymphocytes following cytotoxic chemotherapy.
Description
Date
1991
Publisher
Keywords
Ovarian Cancer
Type
Article
Citation
Effect of verapamil on daunorubicin accumulation in lymphocytes isolated from patients undergoing chemotherapy. 1991, 27 (5):413-5 Cancer Chemother. Pharmacol.