DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
Mateo, J Carreira, S Sandhu, S Miranda, S Mossop, H Perez-Lopez, R Nava Rodrigues, D Robinson, D Omlin, A Tunariu, N
Mateo, J
Carreira, S
Sandhu, S
Miranda, S
Mossop, H
Perez-Lopez, R
Nava Rodrigues, D
Robinson, D
Omlin, A
Tunariu, N
Citations
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Abstract
Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibition with olaparib.
Authors
Mateo, J
Carreira, S
Sandhu, S
Miranda, S
Mossop, H
Perez-Lopez, R
Nava Rodrigues, D
Robinson, D
Omlin, A
Tunariu, N
Boysen, G
Porta, N
Flohr, P
Gillman, A
Figueiredo, I
Paulding, C
Seed, G
Jain, S
Ralph, C
Protheroe, A
Hussain, S
Jones, R
Elliott, Tony
McGovern, U
Bianchini, D
Goodall, J
Zafeiriou, Z
Williamson, C
Ferraldeschi, R
Riisnaes, R
Ebbs, B
Fowler, G
Roda, D
Yuan, W
Wu, Y
Cao, X
Brough, R
Pemberton, H
A'Hern, R
Swain, A
Kunju, L
Eeles, R
Attard, G
Lord, C
Ashworth, A
Rubin, M
Knudsen, K
Feng, F
Chinnaiyan, A
Hall, E
de Bono, J
Carreira, S
Sandhu, S
Miranda, S
Mossop, H
Perez-Lopez, R
Nava Rodrigues, D
Robinson, D
Omlin, A
Tunariu, N
Boysen, G
Porta, N
Flohr, P
Gillman, A
Figueiredo, I
Paulding, C
Seed, G
Jain, S
Ralph, C
Protheroe, A
Hussain, S
Jones, R
Elliott, Tony
McGovern, U
Bianchini, D
Goodall, J
Zafeiriou, Z
Williamson, C
Ferraldeschi, R
Riisnaes, R
Ebbs, B
Fowler, G
Roda, D
Yuan, W
Wu, Y
Cao, X
Brough, R
Pemberton, H
A'Hern, R
Swain, A
Kunju, L
Eeles, R
Attard, G
Lord, C
Ashworth, A
Rubin, M
Knudsen, K
Feng, F
Chinnaiyan, A
Hall, E
de Bono, J
Affiliation
Description
Date
2015-10-29
Publisher
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Keywords
Type
Article
Citation
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. 2015, 373 (18):1697-708 N Engl J Med