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Resolving the dark side of therapy-driven cancer cell death.
Bonavita, Eduardo Pelly, Victoria S Zelenay, Santiago
Bonavita, Eduardo
Pelly, Victoria S
Zelenay, Santiago
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Abstract
In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation. Resolvins, a class of lipid mediators, counteract this effect, representing an attractive target for therapeutic intervention.
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2018-01-02
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Resolving the dark side of therapy-driven cancer cell death. 2018, 215(1): 9-11 J Exp Med