Publication

Epidermal growth factor receptor-targeted therapy.

West, Catharine M L
; 
Joseph, L
; 
Bhana, Sara
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Abstract
High epidermal growth factor receptor (EGFR) expression is a feature of human tumours and is an adverse prognostic factor for radiotherapy outcome. High expression is associated with benefit from accelerated radiotherapy in patients with head and neck squamous cell carcinoma. Anti-EGFR strategies potentiate the effects of radiotherapy and the inhibition of deoxyribonucleic acid repair appears to be important amongst a wide range of mechanisms, which include effects on angiogenesis, differentiation and the immunological response. There is considerable interest in exploring combined modality therapies involving radiation and EGFR antagonists for the curative treatment of cancer patients. Important issues in designing new trials are to investigate optimal scheduling and to establish biobanks to develop biomarkers for future patient selection.
Authors
West, Catharine M L
Joseph, L
Bhana, Sara
Affiliation
Academic Radiation Oncology, The University of Manchester, Christie Hospital, Manchester M20 4BX, UK. catharine.west@manchester.ac.uk
Description
Date
2008-10
Publisher
Collections
All Christie Publications
Academic Department of Radiation Oncology - ADRO
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Keywords
EGFR
Epidermal Growth Factor Receptor
Radiotherapy
Head and Neck Cancer
Uterine Cervical Cancer
Type
Article
Citation
Epidermal growth factor receptor-targeted therapy. 2008, 81 Spec No 1:S36-44 Br J Radiol
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/55821
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