Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma.
Trucco, Lucas D Mundra, Piyushkumar A Hogan, Kate Garcia-Martinez, Pablo Viros, Amaya Mandal, Amit Kumar Macagno, N Gaudy-Marqueste, C Allan, D Baenke, Franziska
Trucco, Lucas D
Mundra, Piyushkumar A
Hogan, Kate
Garcia-Martinez, Pablo
Viros, Amaya
Mandal, Amit Kumar
Macagno, N
Gaudy-Marqueste, C
Allan, D
Baenke, Franziska
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Abstract
Erratum in
Publisher Correction: Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. [Nat Med. 2018]
Abstract
The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.
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Date
2018
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Article
Citation
Trucco LD, Mundra PA, Hogan K, Garcia-Martinez P, Viros A, Mandal AK, et al. Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma. Nat Med. 2018 Dec 3.