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Emulating the delivery of sawtooth proton arc therapy plans on a cyclotron-based proton beam therapy system
Burford-Eyre, S. Aitkenhead, Adam Aylward, Jack D Henthorn, Nicholas T Ingram, Samuel P Mackay, Ranald Manger, Samuel Sitch, Peter Warmenhoven, John-William
Burford-Eyre, S.
Aitkenhead, Adam
Aylward, Jack D
Henthorn, Nicholas T
Ingram, Samuel P
Mackay, Ranald
Manger, Samuel
Sitch, Peter
Warmenhoven, John-William
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Abstract
Purpose: To evaluate and compare the deliverability of 'sawtooth' proton arc therapy (PAT) plans relative to static intensity modulated proton therapy (IMPT) at a cyclotron-based clinical facility. Methods: The delivery of single and dual arc Sawtooth PAT plans for an abdominal CT phantom and multiple clinical cases of brain, head and neck (H&N) and base of skull (BoS) targets was emulated under the step-and-shoot and continuous PAT delivery regimes and compared to that of a corresponding static IMPT plan. Results: Continuous PAT delivery increased the time associated with beam delivery and gantry movement in single/dual PAT plans by 4.86/7.34 min (brain), 7.51/12.40 min (BoS) and 6.59/10.57 min (H&N) on average relative to static IMPT. Step-and-shoot PAT increased this delivery time further by 4.79 min on average as the delivery was limited by gantry motion. Conclusions: The emulator can approximately model clinical sawtooth PAT delivery but requires experimental validation. No clear benefit was observed regarding beam-on time for sawtooth PAT relative to static IMPT.
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Date
2024
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Burford-Eyre S, Aitkenhead A, Aylward JD, Henthorn NT, Ingram SP, Mackay R, et al. Emulating the Delivery of Sawtooth Proton Arc Therapy Plans on a Cyclotron-Based Proton Beam Therapy System. Cancers (Basel). 2024 Sep 27;16(19). PubMed PMID: 39409935. Pubmed Central PMCID: PMC11475827. Epub 2024/10/16. eng.