Autologous lymphocytes as vectors to target therapeutic radiation, using indium-114m, in patients with lymphoid cell malignancy.
Murby, Brian Gunton, Deborah Owens, Susan E Hoyes, Katherine P Sharma, Harbans L Smith, Anne-Marie Chang, James Van Kessel, Bregje Nuttall, Pamela M
Murby, Brian
Gunton, Deborah
Owens, Susan E
Hoyes, Katherine P
Sharma, Harbans L
Smith, Anne-Marie
Chang, James
Van Kessel, Bregje
Nuttall, Pamela M
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Abstract
Autologous lymphocytes provide a potential vector for the delivery of a cytotoxic agent in patients with lymphoid cell malignancy. This report describes a phase I-II study using autologous lymphocytes to target the radionuclide indium-114m ((114m)In) in patients with refractory chronic lymphocytic leukaemia or small lymphocytic non-Hodgkin's lymphoma. Nineteen patients, the majority of whom had been heavily pretreated with conventional chemotherapy and radiotherapy, received between 69 and 211 MBq (114m)In-labelled autologous lymphocytes. Approximately 80% of the administered activity was localized in the liver and spleen, with around 5% accumulating in the bone marrow. Ten patients (53%) responded (one complete response and nine partial responses). The median duration of response was 7 months. The median survival for the responders was 14 months and for the non-responders was 3 months. The first notable response in every patient was a fall in peripheral lymphocyte count. The indium treatment was not associated with any subjective toxicity, although all patients suffered from myelosuppression, with thrombocytopenia being the dose-limiting factor. This study has demonstrated a significant anti-tumour effect in a group of patients with late-stage highly resistant disease.
Description
Date
2002-11
Publisher
Collections
Keywords
Chronic B-Cell Lymphocytic Leukaemia
Type
Article
Citation
Autologous lymphocytes as vectors to target therapeutic radiation, using indium-114m, in patients with lymphoid cell malignancy. 2002, 119 (2):459-66 Br. J. Haematol.