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An update on pancreatic cancer imaging, staging, and use of the PACT-UK radiology template pre- and post-neoadjuvant treatment
Corallo, C. Al-Adhami, A. S. Jamieson, N. Valle, Juan Radhakrishna, Ganesh Moir, J. Albazaz, R.
Corallo, C.
Al-Adhami, A. S.
Jamieson, N.
Valle, Juan
Radhakrishna, Ganesh
Moir, J.
Albazaz, R.
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Abstract
Pancreatic ductal adenocarcinoma continues to have a poor prognosis, although recent advances in neoadjuvant treatments (NATs) have provided some hope. Imaging assessment of suspected tumours can be challenging and requires a specific approach, with pancreas protocol CT being the primary imaging modality for staging with other modalities used as problem-solving tools to facilitate appropriate management. Imaging assessment post NAT can be particularly difficult due to a current lack of robust radiological criteria to predict response and differentiate treatment induced fibrosis/inflammation from residual tumour. This review aims to provide an update of pancreatic ductal adenocarcinoma with particular focus on three points: tumour staging pre- and post-NAT including vascular assessment, structured reporting with introduction of the PAncreatic Cancer reporting Template-UK (PACT-UK) radiology template, and the potential future role of artificial intelligence in the diagnosis and staging of pancreatic cancer.
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Date
2024
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Article
Citation
Corallo C, Al-Adhami AS, Jamieson N, Valle J, Radhakrishna G, Moir J, et al. An update on pancreatic cancer imaging, staging, and use of the PACT-UK radiology template pre- and post-neoadjuvant treatment. The British journal of radiology. 2025 Jan 1;98(1165):13-26. PubMed PMID: 39460945. Pubmed Central PMCID: PMC11652714. Epub 2024/10/26. eng.