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Antagonizing self-renewal in acute myeloid leukemia: ID2 takes the stage.
Deb, Gauri Somervaille, Tim C P
Deb, Gauri
Somervaille, Tim C P
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Abstract
E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.
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2016-07-11
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Antagonizing self-renewal in acute myeloid leukemia: ID2 takes the stage. 2016, 30 (1):5-7 Cancer Cell