DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents.
O'Connor, James P B Jackson, Alan Parker, Geoff J M
O'Connor, James P B
Jackson, Alan
Parker, Geoff J M
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Abstract
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. Evidence of drug efficacy and dose-dependent response has been demonstrated with some angiogenesis inhibitors. This review highlights the critical issues that influence T(1)-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date.
Description
Date
2007-01-29
Publisher
Collections
Keywords
Tumour Markers
Type
Article
Citation
DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. 2007, 96 (2):189-95 Br. J. Cancer