Which are the leukaemic cells?
Lajtha, L G
Lajtha, L G
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Abstract
Two features are known about acute myeloid leukaemia in man: (1) the long time-scale from identifiable leukaemogenic stimulus and onset of the clinical disease and (2) the successful induction and duration of long clinical remission. These indicate three probabilities: First, that the target cell for leukaemogenetic insult (in AML) is the pluripotent stem cell; second, that the leukaemic stem line is a small minority population within the total leukaemic cell mass; third, when the leukaemic stem line is not greatly exceeding the normal stem cell numbers, its proliferation may be still under partial control.
Authors
Description
Date
1981
Publisher
Collections
Keywords
Leukaemia
Type
Citation
Which are the leukaemic cells? 1981, 7 (1):45-62 Blood Cells