Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression.
Duggan-Keen, Margaret F Keating, P J Stevens, F R Adam Sinnott, P Snijders, P J Walboomers, J M Davidson, Susan E Hunter, Robin D Dyer, P A Stern, Peter L
Duggan-Keen, Margaret F
Keating, P J
Stevens, F R Adam
Sinnott, P
Snijders, P J
Walboomers, J M
Davidson, Susan E
Hunter, Robin D
Dyer, P A
Stern, Peter L
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Abstract
No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.
Description
Date
1996-08
Publisher
Keywords
Uterine Cervical Cancer
Tumour Virus Infections
Tumour Virus Infections
Type
Article
Citation
Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression. 1996, 23 (4):275-84 Eur. J. Immunogenet.