Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy.
Duff, Sarah E Li, Chenggang Jeziorska, M Kumar, Shant Saunders, Mark P Sherlock, D O'Dwyer, Sarah T
Duff, Sarah E
Li, Chenggang
Jeziorska, M
Kumar, Shant
Saunders, Mark P
Sherlock, D
O'Dwyer, Sarah T
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Abstract
Vascular endothelial growth factor-C (VEGF-C) and VEGF-D are members of the VEGF family of cytokines and have angiogenic and lymphangiogenic actions. In gastric adenocarcinoma, VEGF-C mRNA and tissue protein expression correlate with lymphatic invasion, lymph node metastasis and in some reports, venous invasion and reduced 5-year survival. Patients with gastric adenocarcinomas containing high levels of VEGF-C expression have significantly reduced 5-year survival rates, and VEGF-C expression is an independent prognostic risk factor for death. The role of VEGF-C in oesophageal squamous and colorectal cancer and VEGF-D in colorectal cancer is not clear, with conflicting reports in the published literature. In order to exploit potential therapeutic applications, further research is necessary to define the precise roles of these cytokines in health and disease.
Description
Date
2003-08-04
Publisher
Collections
Keywords
Colorectal Cancer
Oesophageal Cancer
Stomach Cancer
Cancer Invasiveness
Oesophageal Cancer
Stomach Cancer
Cancer Invasiveness
Type
Article
Citation
Vascular endothelial growth factors C and D and lymphangiogenesis in gastrointestinal tract malignancy. 2003, 89 (3):426-30 Br. J. Cancer