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O6-alkyltransferase activity in normal human gastric mucosa.
Dyke, G W Craven, J L Hall, R Cooper, Donald P Soballa, G Garner, R C
Dyke, G W
Craven, J L
Hall, R
Cooper, Donald P
Soballa, G
Garner, R C
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Abstract
The spectrum of activity of the DNA repair enzyme O6-alkyltransferase has been studied in a large series of normal stomachs in order to establish the baseline range of values for this enzyme. Sixty-eight patients with histologically normal stomachs were biopsied during the course of upper gastrointestinal endoscopy and the biopsies assayed for O6-alkyl-transferase activity. A wide spectrum of activity was found with values ranging from 38 fmol O6-guanine extracted/mg protein to over 400 fmol/mg. This suggests that there may be wide inter-individual differences in susceptibility to alkylating actions in the human gastric mucosa.
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Date
1990-11-05
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Article
Citation
O6-alkyltransferase activity in normal human gastric mucosa. 1990, 54 (3):147-51 Cancer Lett.