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Synthesis and evaluation of double bond substituted combretastatins.
Hadfield, John A Gaukroger, Keira Hirst, Nicholas Weston, Anna P Lawrence, Nicholas J McGown, Alan T
Hadfield, John A
Gaukroger, Keira
Hirst, Nicholas
Weston, Anna P
Lawrence, Nicholas J
McGown, Alan T
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Abstract
A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.
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Date
2005-06
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Article
Citation
Synthesis and evaluation of double bond substituted combretastatins. 2005, 40 (6):529-41 Eur J Med Chem