Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer
Nalio Ramos, R. Missolo-Koussou, Y. Gerber-Ferder, Y. Bromley, C. P. Bugatti, M. Núñez, N. G. Tosello Boari, J. Richer, W. Menger, L. Denizeau, J.
Nalio Ramos, R.
Missolo-Koussou, Y.
Gerber-Ferder, Y.
Bromley, C. P.
Bugatti, M.
Núñez, N. G.
Tosello Boari, J.
Richer, W.
Menger, L.
Denizeau, J.
Citations
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Abstract
Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.
Authors
Nalio Ramos, R.
Missolo-Koussou, Y.
Gerber-Ferder, Y.
Bromley, C. P.
Bugatti, M.
Núñez, N. G.
Tosello Boari, J.
Richer, W.
Menger, L.
Denizeau, J.
Sedlik, C.
Caudana, P.
Kotsias, F.
Niborski, L. L.
Viel, S.
Bohec, M.
Lameiras, S.
Baulande, S.
Lesage, L.
Nicolas, A.
Meseure, D.
Vincent-Salomon, A.
Reyal, F.
Dutertre, C. A.
Ginhoux, F.
Vimeux, L.
Donnadieu, E.
Buttard, B.
Galon, J.
Zelenay, S.
Vermi, W.
Guermonprez, P.
Piaggio, E.
Helft, J.
Missolo-Koussou, Y.
Gerber-Ferder, Y.
Bromley, C. P.
Bugatti, M.
Núñez, N. G.
Tosello Boari, J.
Richer, W.
Menger, L.
Denizeau, J.
Sedlik, C.
Caudana, P.
Kotsias, F.
Niborski, L. L.
Viel, S.
Bohec, M.
Lameiras, S.
Baulande, S.
Lesage, L.
Nicolas, A.
Meseure, D.
Vincent-Salomon, A.
Reyal, F.
Dutertre, C. A.
Ginhoux, F.
Vimeux, L.
Donnadieu, E.
Buttard, B.
Galon, J.
Zelenay, S.
Vermi, W.
Guermonprez, P.
Piaggio, E.
Helft, J.
Affiliation
Description
Date
2022
Publisher
Collections
Keywords
Type
Article
Citation
Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, et al. Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer. Cell. 2022;185(7):1189-207.e25.