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Implications for immunosurveillance of altered HLA class I phenotypes in human tumours.
Garrido, F Ruiz-Cabello, F Cabrera, T Pérez-Villar, J J López-Botet, M Duggan-Keen, M Stern, Peter L
Garrido, F
Ruiz-Cabello, F
Cabrera, T
Pérez-Villar, J J
López-Botet, M
Duggan-Keen, M
Stern, Peter L
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Abstract
HLA class I downregulation is a frequent event associated with tumour invasion and development. Altered HLA class I tumour phenotypes can have profound effects on T-cell and natural killer (NK)-cell antitumour responses. Here, Federico Garrido and colleagues analyse these altered tumour phenotypes in detail, indicating their potential relevance for implementation of immunotherapeutic protocols and strategies to overcome tumour escape mechanisms.
Description
Date
1997-02
Publisher
Collections
Keywords
Cancer
Type
Article
Citation
Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. 1997, 18 (2):89-95 Immunol. Today