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Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial.
Mulvenna, P Nankivell, M Barton, R Faivre-Finn, Corinne Wilson, P McColl, E Moore, B Brisbane, I Ardron, D Holt, T
Mulvenna, P
Nankivell, M
Barton, R
Faivre-Finn, Corinne
Wilson, P
McColl, E
Moore, B
Brisbane, I
Ardron, D
Holt, T
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Abstract
Whole brain radiotherapy (WBRT) and dexamethasone are widely used to treat brain metastases from non-small cell lung cancer (NSCLC), although there have been no randomised clinical trials showing that WBRT improves either quality of life or overall survival. Even after treatment with WBRT, the prognosis of this patient group is poor. We aimed to establish whether WBRT could be omitted without a significant effect on survival or quality of life.
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2016-09-02
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Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. 2016, Lancet