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Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples.

Hall, J S
; 
Leong, Hui Sun
; 
Armenoult, L S C
; 
Newton, G E
; 
Valentine, Helen R
; 
Irlam, Joely J
; 
Möller-Levet, Carla S
; 
Sikand, Kanwal A
; 
Pepper, Stuart D
; 
Miller, Crispin J
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Abstract
Degradation and chemical modification of RNA in formalin-fixed paraffin-embedded (FFPE) samples hamper their use in expression profiling studies. This study aimed to show that useful information can be obtained by Exon-array profiling archival FFPE tumour samples.
Authors
Hall, J S
Leong, Hui Sun
Armenoult, L S C
Newton, G E
Valentine, Helen R
Irlam, Joely J
Möller-Levet, Carla S
Sikand, Kanwal A
Pepper, Stuart D
Miller, Crispin J
West, Catharine M L
Affiliation
Translational Radiobiology Group, School of Cancer and Enabling Sciences, Manchester Academic Health Science Centre, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
Description
Date
2011-03-15
Publisher
Collections
All Christie Publications
Academic Department of Radiation Oncology - ADRO
All Paterson Institute for Cancer Research
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Keywords
Type
Article
Citation
Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples. 2011, 104 (6):971-81 Br J Cancer
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/136158
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