Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.
Krebs, Matthew G Hou, Jian-Mei Sloane, Robert Lancashire, Lee J Priest, Lynsey Ward, Timothy H Backen, Alison C Clack, Glen Hughes, Andrew
Krebs, Matthew G
Hou, Jian-Mei
Sloane, Robert
Lancashire, Lee J
Priest, Lynsey
Ward, Timothy H
Backen, Alison C
Clack, Glen
Hughes, Andrew
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Abstract
Epithelial circulating tumor cells (CTCs) are detectable in patients with non-small cell lung cancer (NSCLC). However, epithelial to mesenchymal transition, a widely reported prerequisite for metastasis, may lead to an underestimation of CTC number. We compared directly an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs. Molecular characteristics of CTCs were also explored.
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Date
2012-02
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Article
Citation
Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches. 2012, 7 (2):306-15 J Thorac Oncol