Alpha-2-interferon/melphalan/prednisone in previously untreated patients with multiple myeloma: a phase I-II trial.
Cooper, M R Fefer, A Thompson, J Case, D C Kempf, R Sacher, R Neefe, J Bickers, J Scarffe, J Howard Spiegel, R
Cooper, M R
Fefer, A
Thompson, J
Case, D C
Kempf, R
Sacher, R
Neefe, J
Bickers, J
Scarffe, J Howard
Spiegel, R
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Abstract
Alpha-2-interferon (IFN) has demonstrable activity in advanced, relapsing, or refractory multiple myeloma. Because of the in vitro synergism between the IFNs and cytotoxic agents, we conducted a trial of 30 previously untreated patients with multiple myeloma utilizing various doses of alpha-2-IFN in combination with standard oral doses of melphalan and prednisone. The combination was well-tolerated without unusual or unexpected toxic effects. The limiting toxicity included dose-related myelosuppression, and alpha-2-IFN induced flu-like symptoms and fatigue. Response was seen in at least as many patients as would be expected with melphalan and prednisone alone. The maximal tolerated dose for a phase II-III trial was 5.0 X 10(6) IU/m2 of alpha-2-IFN in combination with standard doses of melphalan and prednisone. Future trials should utilize this dose of alpha-2-IFN with dose de-escalation according to tolerance.
Affiliation
Description
Date
1986-04
Publisher
Collections
Keywords
Anticancerous Combined Chemotherapy Protocols
Type
Article
Citation
Alpha-2-interferon/melphalan/prednisone in previously untreated patients with multiple myeloma: a phase I-II trial. 1986, 70 (4):473-6 Cancer Treat Rep