Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen.
O'Connor, James P B Naish, Josephine H Jackson, Alan Waterton, John C Watson, Yvonne Cheung, Susan Buckley, David L McGrath, Deirdre M Buonaccorsi, Giovanni A Mills, Samantha J
O'Connor, James P B
Naish, Josephine H
Jackson, Alan
Waterton, John C
Watson, Yvonne
Cheung, Susan
Buckley, David L
McGrath, Deirdre M
Buonaccorsi, Giovanni A
Mills, Samantha J
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Abstract
Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this study differences in the tissue longitudinal relaxation rate (R(1)) and effective transverse relaxation rate (R(*)(2)), induced by inhalation of pure oxygen and carbogen, were evaluated in 10 healthy subjects. Significant reductions in R(1) were demonstrated following both oxygen and carbogen inhalation in the spleen (both P < 0.001), liver (P = 0.002 air vs. oxygen; P = 0.001 air vs. carbogen), skeletal muscle (both P < 0.001), and renal cortex (P = 0.005 air vs. oxygen; P = 0.008 air vs. carbogen). No significant change in R(*)(2) occurred following pure oxygen in any organ. However, a significant increase in R(*)(2) was observed in the spleen (P < 0.001), liver (P = 0.001), skeletal muscle (P = 0.026), and renal cortex (P = 0.001) following carbogen inhalation, an opposite effect to that observed in many studies of tumor pathophysiology. Changes in R(1) and R(*)(2) were independent of the gas administration order in the spleen and skeletal muscle. These findings suggest that the R(1) and R(*)(2) responses to hyperoxic gases are independent biomarkers of oxygen physiology.
Description
Date
2009-01
Publisher
Keywords
Biomarkers
Type
Article
Citation
Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen. 2009, 61 (1):75-83notMagn Reson Med