RASSF1A polymorphism in familial breast cancer.
Bergqvist, J Latif, A Roberts, S A Hadfield, K D Lalloo, Fiona Evans, D Gareth R Newman, W G
Bergqvist, J
Latif, A
Roberts, S A
Hadfield, K D
Lalloo, Fiona
Evans, D Gareth R
Newman, W G
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Abstract
Inactivation or loss of the tumour suppressor Ras associated domain family 1 isoform A (RASSF1A) allele has been described in breast cancer. Recently, a missense polymorphism predicting p.A331S in RASSF1A was associated with an increased risk of breast cancer and early-onset breast cancer in BRCA1 and BRCA2 mutation carriers. We genotyped p.A331S RASSF1A in 854 independent, familial, white breast cancer patients (645 BRCA mutation negative, 119 BRCA1 and 90 BRCA2 positive) and compared the genotype in 331 healthy women. The RASSF1A p.A331S variant was not more common in the familial breast cancer cases than in the controls (P = 0.27). Subset analysis demonstrated no association in the BRCA1 (P = 0.26), BRCA2 (P = 0.16) or BRCA negative (P = 0.30) samples. Hence, the RASSF1A p.A331S polymorphism is not confirmed as a significant germline contributor to familial breast cancer susceptibility.
Description
Date
2010-09
Publisher
Collections
Keywords
BRCA1
BRCA2
Breast Cancer
Familial
RASSF1A
BRCA2
Breast Cancer
Familial
RASSF1A
Type
Article
Citation
RASSF1A polymorphism in familial breast cancer. 2010, 9 (3):263-5 Fam Cancer