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Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications.

Meyer, Stefan
; 
Neitzel, H
; 
Tönnies, H
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Abstract
Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone marrow surveillance is an important part of the clinical management of FA and often reveals cytogenetic aberrations. Here, we review bone marrow findings in FA and discuss the clinical and biological implications of chromosomal aberrations associated with leukemic transformation.
Authors
Meyer, Stefan
Neitzel, H
Tönnies, H
Affiliation
c/o Young Oncology Unit, Department of Paediatric and Adolescent Oncology, Christie Hospital, Wilmslow Road, Manchester M20 6XB, UK.
Description
Date
2012
Publisher
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All Christie Publications
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Type
Article
Citation
Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: clinical and biological implications. 2012, 2012:349837 Anemia
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Volume Title
URI
http://hdl.handle.net/10541/251617
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