Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study.
Monaghan, Phillip J Kyriacou, Angelos Sturgeon, C Davies, A Trainer, Peter J White, A Higham, Claire E
Monaghan, Phillip J
Kyriacou, Angelos
Sturgeon, C
Davies, A
Trainer, Peter J
White, A
Higham, Claire E
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Abstract
It is recognized that measurement of ACTH-precursor peptides including proopiomelanocortin (POMC) has clinical utility in identifying the aetiology of Cushing's syndrome. Recent data have also demonstrated cross-reactivity of POMC in ACTH immunoassays used in clinical laboratories. The aim of this study was to assess the cross-reactivity of POMC in the main commercial immunoassays for ACTH and to survey the awareness of laboratory professionals to this potential interference.
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Date
2016-06-03
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Proopiomelanocortin interference in the measurement of adrenocorticotrophic hormone: a United Kingdom National External Quality Assessment Service study. 2016: Clin Endocrinol