Pseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases.
Banerjee, Saumitra S Eyden, Brian P Wells, S McWilliam, L J Harris, Martin
Banerjee, Saumitra S
Eyden, Brian P
Wells, S
McWilliam, L J
Harris, Martin
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Abstract
Seven cases of carcinoma mimicking angiosarcoma occurring in skin (3 cases), breast (3) and lung (1) are described. The cutaneous, pulmonary and one of the breast carcinomas were poorly differentiated and squamous in type; the other two breast tumours were poorly differentiated ductal carcinomas with focal squamous differentiation. Histologically, the pseudoangiosarcomatous pattern was due to complex anastomosing channels and spaces lined by neoplastic cells. The spaces contained hyaluronic acid. The neoplastic cells exhibited cytokeratin positivity but yielded negative results with the endothelial cell markers, factor VIII-related antigen and CD 34 (QB-END/10). Two breast tumours showed binding of UEA-1. Ultrastructurally, unequivocal epithelial differentiation was demonstrated in six of the cases. Pathogenetically, these tumours appeared to be variants of acantholytic squamous cell carcinoma. Recognition of this unusual form of carcinoma is important, as an incorrect diagnosis of angiosarcoma may lead to inappropriate treatment and prognostication.
Description
Date
1992-07
Publisher
Collections
Keywords
Breast Cancer
Lung Cancer
Skin Cancer
Lung Cancer
Skin Cancer
Type
Article
Citation
Pseudoangiosarcomatous carcinoma: a clinicopathological study of seven cases. 1992, 21 (1):13-23 Histopathology