BA08: An open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract.
Griffiths, G Cowan, Richard A Grigor, K Uscinska, B Sydes, M Russell, M
Griffiths, G
Cowan, Richard A
Grigor, K
Uscinska, B
Sydes, M
Russell, M
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Abstract
BACKGROUND:
Pure squamous cell carcinoma (SCC) of the urinary tract is rare in the UK and has a poor prognosis compared with transitional cell carcinoma (TCC). Cisplatin based chemotherapy has been shown to be effective in TCC.
METHODS:
Patients with T3-T4, pelvic relapsed, nodal or metastatic SCC of the urinary tract were recruited into an open-label, single-arm, non-randomised, phase 2 trial evaluating the activity and safety of cisplatin, methotrexate and vinblastine (CMV) chemotherapy. CMV was given as three 21-day cycles of methotrexate 30mg/m2 (day 1 & 8), vinblastine 4mg/m2 (day 1 & 8) and cisplatin 100mg/m2 (day 2).
RESULTS:
38 patients were recruited. Overall response was 39% (95% CI 24%, 55%)-13% CR and 26% PR. Median OS was 7.8 months (95% CI 3.4, 12.6) with 39% 1-year survival. Toxicity was acceptable.
CONCLUSION:
CMV is well tolerated and active in patients with pure SCC of the urinary tract.
Description
Date
2019
Publisher
Collections
Keywords
Type
Article
Citation
Griffiths GO, Cowan RA, Grigor KM, Uscinska BM, Sydes M, Russell M. BA08: An open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract. PLoS One. 2019;14(1):e0210785.