DNA analysis by flow cytometry in malignant pleural mesothelioma: relationship to histology and survival.
Dazzi, H Thatcher, Nick Hasleton, Philip S Chatterjee, A K Lawson, R A
Dazzi, H
Thatcher, Nick
Hasleton, Philip S
Chatterjee, A K
Lawson, R A
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Abstract
In a retrospective study of 70 patients with malignant pleural mesothelioma, 168 formalin-fixed, paraffin-embedded tumour specimens were examined for DNA content by flow cytometry. In 20 patients where two or more blocks of the same tumour were available, there was considerable agreement between ploidy status and S-phase percentage in the different specimens. There were no significant differences for survival for patients who had been exposed to asbestos and those in whom no exposure could be elicited, nor for aneuploid and diploid tumours. The S-phase content was examined for different areas of the same tumour and the percentages were largely in agreement. However, those patients who had tumours with an S-phase percentage greater than the median (6 per cent) had a significantly shorter survival than those with tumours of lower S-phase percentage. Differences in DNA content and other cell cycle parameters were not associated with the histological subtypes.
Description
Date
1990-09
Publisher
Collections
Keywords
Cancer DNA
Pleural Cancer
Pleural Cancer
Type
Article
Citation
DNA analysis by flow cytometry in malignant pleural mesothelioma: relationship to histology and survival. 1990, 162 (1):51-5 J Pathol