Dose intensity in small cell lung cancer.
Thatcher, Nick Lee, Siow Ming Woll, Penella J Middleton, Mark R Anderson, Heather Burt, Paul A Stout, Ronald
Thatcher, Nick
Lee, Siow Ming
Woll, Penella J
Middleton, Mark R
Anderson, Heather
Burt, Paul A
Stout, Ronald
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Abstract
Evidence from preclinical models and from clinical trials describing the importance of dose intensity in securing a better treatment outcome is reviewed. Recent randomized trials have shown statistically significant survival benefits with higher-dose, accelerated chemotherapy regimens with and without granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. The novel use of peripheral blood progenitor cells contained in whole blood autotransfusions, which allow a marked increase in dose intensity of an ifosfamide/carboplatin/etoposide regimen, could provide a much easier method of delivering dose-intensive chemotherapy than previously available.
Description
Date
1998-04
Publisher
Collections
Keywords
Lung Cancer
Haematopoietic Stem Cell Transplantation
Haematopoietic Stem Cell Transplantation
Type
Article
Citation
Dose intensity in small cell lung cancer. 1998, 25 (2 Suppl 4):12-8; discussion 45-8 Semin. Oncol.