Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer.
Cuzick, J Stewart, H Peto, R Baum, M Fisher, B Host, H Lythgoe, J P Ribeiro, G Scheurlen, H Wallgren, A
Cuzick, J
Stewart, H
Peto, R
Baum, M
Fisher, B
Host, H
Lythgoe, J P
Ribeiro, G
Scheurlen, H
Wallgren, A
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Abstract
An overview of the mortality results of the mature trials in which radiotherapy was a randomized option after simple or radical mastectomy is presented. The principal aim of the overview was to study long-term survival, and recent trials, often including chemotherapy options, have not been included. A total of 7941 patients were entered into these trials and 4148 deaths occurred. No differences were found in survival in the first 10 years of follow-up, in trials employing either radical mastectomy or simple mastectomy. Follow-up information after 10 years came mostly from trials employing radical mastectomy with or without irradiation, and in these trials a significant excess of deaths was observed among patients given radiotherapy (P less than 0.001, all trials; P = 0.002, radical mastectomy trials only). Further data collection will be necessary to determine which causes of death are elevated.
Affiliation
Description
Date
1987-01
Publisher
Collections
Keywords
Breast Cancer
Type
Article
Citation
Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer. 1987, 71 (1):15-29 Cancer Treat Rep