Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.
Barraclough, Jane Hodgkinson, Cassandra L Hogg, Alison Dive, Caroline Welman, Arkadiusz
Barraclough, Jane
Hodgkinson, Cassandra L
Hogg, Alison
Dive, Caroline
Welman, Arkadiusz
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Abstract
Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in colorectal cancer cells, remain elusive. To study the consequences of increases in c-Yes levels and activity in later stages of colorectal carcinogenesis, we developed human colorectal cancer cell lines in which c-Yes levels and activity can be inducibly increased by a tightly controlled expression of wild-type c-Yes or by constitutively active mutants of c-Yes, c-YesY537F, and c-Yes Delta t6aa. c-Yes induction resulted in increased cell motility but did not promote proliferation either in vitro or in vivo. These results suggest that in later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread and metastasis rather than tumor growth.
Description
Date
2007-09
Publisher
Collections
Keywords
Cell Line Tumour
Colorectal Cancer
Cancer Proteins
Cancer Transplantation
Colorectal Cancer
Cancer Proteins
Cancer Transplantation
Type
Article
Citation
Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. 2007, 9 (9):745-54 Neoplasia