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Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review.
Freeman, Karoline Saunders, Mark P Uthman, Olalekan A Taylor-Phillips, Sian Connock, Martin Court, Rachel Gurung, Tara Sutcliffe, Paul Clarke, Aileen
Freeman, Karoline
Saunders, Mark P
Uthman, Olalekan A
Taylor-Phillips, Sian
Connock, Martin
Court, Rachel
Gurung, Tara
Sutcliffe, Paul
Clarke, Aileen
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Abstract
Pharmacokinetic guided dosing of 5-fluorouracil chemotherapies to bring plasma 5-fluorouracil into a desired therapeutic range may lead to fewer side effects and better patient outcomes. High performance liquid chromatography and a high throughput nanoparticle immunoassay (My5-FU) have been used in conjunction with treatment algorithms to guide dosing. The objective of this study was to assess accuracy, clinical effectiveness and safety of plasma 5-fluorouracil guided dose regimen(s) versus standard regimens based on body surface area in colorectal cancer.
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2016
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Is monitoring of plasma 5-fluorouracil levels in metastatic / advanced colorectal cancer clinically effective? A systematic review. 2016, 16:523 BMC Cancer