Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom.
Shanley, Susan McReynolds, Kate Ardern-Jones, Audrey Ahern, Roger Fernando, Indrajit Yarnold, John Evans, D Gareth R Eccles, Diana Hodgson, Shirley V Ashley, Sue
Shanley, Susan
McReynolds, Kate
Ardern-Jones, Audrey
Ahern, Roger
Fernando, Indrajit
Yarnold, John
Evans, D Gareth R
Eccles, Diana
Hodgson, Shirley V
Ashley, Sue
Citations
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Abstract
PURPOSE: To evaluate acute toxicity induced by chemotherapy for breast cancer in a retrospective study of 62 BRCA1/2 mutation carriers matched 1:1 with women who had treatment for sporadic disease in the United Kingdom between 1983 and 2003. EXPERIMENTAL DESIGN: All participants were interviewed by one of two researchers using standardized questionnaires, and their medical records were reviewed by one research nurse. The two main regimens received were cyclophosphamide, methotrexate, and fluorouracil and fluorouracil, epirubicin, and cyclophosphamide. The proportion of cases and controls receiving anthracycline-based treatment was equivalent, but fewer BRCA1 cases received this treatment than did BRCA2 mutation carriers. Toxicity was documented using the Eastern Cooperative Oncology Group Common Toxicity Criteria for hematologic, infective, and gastrointestinal toxicities. No increase in toxicity was seen in BRCA1/2 mutation carriers. RESULTS: The only significant difference was that neutropenia was less evident in BRCA2 mutation carriers than in either BRCA1 mutation carriers or controls. As a result, there was no requirement for dose reduction among BRCA2 mutation carriers, in contrast to 10 of 39 BRCA1 carriers and 16 of 62 controls (P = 0.02). CONCLUSIONS: This result has implications for therapy and indicates that women with mutations in BRCA1 and BRCA2 may be given the same doses of chemotherapy as noncarriers.
Authors
Shanley, Susan
McReynolds, Kate
Ardern-Jones, Audrey
Ahern, Roger
Fernando, Indrajit
Yarnold, John
Evans, D Gareth R
Eccles, Diana
Hodgson, Shirley V
Ashley, Sue
Ashcroft, Linda
Tutt, Andrew
Bancroft, Elizabeth
Short, Susan
Smith, Ian
Gui, Gerald
Barr, Lester
Baildam, Andrew D
Howell, Anthony
Royle, Gavin
Pierce, Lori
Easton, Douglas
Eeles, Rosalind
McReynolds, Kate
Ardern-Jones, Audrey
Ahern, Roger
Fernando, Indrajit
Yarnold, John
Evans, D Gareth R
Eccles, Diana
Hodgson, Shirley V
Ashley, Sue
Ashcroft, Linda
Tutt, Andrew
Bancroft, Elizabeth
Short, Susan
Smith, Ian
Gui, Gerald
Barr, Lester
Baildam, Andrew D
Howell, Anthony
Royle, Gavin
Pierce, Lori
Easton, Douglas
Eeles, Rosalind
Description
Date
2006-12-01
Publisher
Collections
Keywords
Breast Cancer
Cancer Staging
Cancer Staging
Type
Article
Citation
Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom. 2006, 12 (23):7033-8 Clin. Cancer Res.