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No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study.

Barnett, G
; 
Coles, C
; 
Burnet, N
; 
Pharoah, P
; 
Wilkinson, J
; 
West, Catharine M L
; 
Elliott, Rebecca M
; 
Baynes, C
; 
Dunning, A
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Abstract
Several small studies have reported associations between TGFB1 single nucleotide polymorphisms (SNPs), considered to increase secretion of TGF-β1, and greater than 3-fold increases in incidence of fibrosis - an indicator of late toxicity after radiotherapy in breast cancer patients.
Authors
Barnett, G
Coles, C
Burnet, N
Pharoah, P
Wilkinson, J
West, Catharine M L
Elliott, Rebecca M
Baynes, C
Dunning, A
Affiliation
Department of Oncology, University of Cambridge, Cambridge, UK. gillbarnett@doctors.org.uk
Description
Date
2010-10
Publisher
Collections
All Paterson Institute for Cancer Research
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Keywords
Radiotherapy
Breast Cancer
Genetics
TGFB1
Type
Article
Citation
No association between SNPs regulating TGF-β1 secretion and late radiotherapy toxicity to the breast: results from the RAPPER study. 2010, 97 (1):9-14 Radiother Oncol
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/120126
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